منابع مشابه
Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats
BACKGROUND Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. METHODS In this study, we prepared levodopa methyl ester (LDME)/benserazide-loaded nanoparticles, which can re...
متن کاملBetaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats
Objective(s): The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. Materials and Methods: Sprague-Dawley male rats were treated with levodopa (LD), betaine (Bet), levodopa plus betaine (LD/Bet), levodopa plus benserazide (LD/Ben), levodopa plus betaine-benserazide (LD/Bet-Ben), and t...
متن کاملSequential Determination of Benserazide and Levodopa by Voltammetric Method using Chloranil as a Mediator
Descrevemos um método eletroquímico para a determinação voltamétrica seqüencial de benserazida e levodopa usando cloroanil (CA) como eletro-catalisador. Para investigar a adequação do CA como mediador na oxidação eletrocatalitica da benserazida e levodopa, em solução aquosa, foram usadas a voltametria cíclica, voltametria de pulso diferencial, cronoamperometria e espectroscopia de impedância el...
متن کاملLevodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats
BACKGROUND Levodopa is the gold standard in the treatment of Parkinson's disease (PD). However, long-term levodopa replacement therapy is accompanied by abnormal involuntary movements (AIMs), known as levodopa-induced dyskinesia (LID). Until now, the precise mechanisms of LID were only partially understood. Previous studies have shown that continuous dopamine stimulation was helpful in reducing...
متن کاملSimultaneous chemiluminometric determination of levodopa and benserazide in a multi-pumping flow system with multivariate calibration.
An automated multi-pumping flow system is proposed for the simultaneous chemiluminometric determination of benserazide and levodopa using multivariate calibration methods. The developed methodology is based on chemiluminescence (CL) emission generated by the reaction of benserazide with luminol, and on a concurrent inhibiting effect of levodopa on this reaction. A multi-pumping flow system comp...
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ژورنال
عنوان ژورنال: Neurology, Neuropsychiatry, Psychosomatics
سال: 2015
ISSN: 2310-1342,2074-2711
DOI: 10.14412/2074-2711-2015-3-93-97